Abstract #302292

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JSM 2003 Abstract #302292
Activity Number: 218
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #302292
Title: Measurement Error and Confidence Intervals for ROC Curves
Author(s): Tor D. Tosteson*+ and John P. Buonaccorsi and Eugene Demidenko
Companies: Dartmouth Medical School and University of Massachusetts and Dartmouth Medical School
Address: One Medical Center Dr., Rubin 7927, Lebanon, NH, 03756,
Keywords: measurement error ; ROC curves ; diagnostic test
Abstract:

Measurement error in a continuous test variable may bias estimates of the summary properties of receiver operating characteristics (ROC) curves. Typically, unbiased measurement error will reduce the diagnostic potential of a continuous test variable. This paper explores the effects of possibly heterogenous measurement error on estimated ROC curves for binormal test variables. Corrected estimators for specific points on the curve are derived under the assumption of known or estimated measurement variances for individual test results. These estimators and associated confidence intervals are robust to the distribution of the measurement error and are shown to be approximately unbiased for moderate size samples in a simulation study. An application from a study of emerging imaging modalities in breast cancer is used to demonstrate the new techniques.

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