Abstract #301954

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JSM 2003 Abstract #301954
Activity Number: 167
Type: Contributed
Date/Time: Monday, August 4, 2003 : 2:00 PM to 3:50 PM
Sponsor: Section on Health Policy Statistics
Abstract - #301954
Title: A Propensity Score Approach for Within-Trial Incremental Cost-Effectiveness Analysis
Author(s): Kevin J. Anstrom*+ and Anastasios A. Tsiatis
Companies: Duke University and North Carolina State University
Address: 8 Fernwood Court, Durham, NC, 27713,
Keywords: observational studies ; incremenatal net benefit ; censored data
Abstract:

We present a method, based on weighted estimators, for calculating the incremental cost and effectiveness measures between two treatments in randomized or observational studies with censored data. Assuming that the treatment assignment and censoring mechanisms are consistently estimated, this method yields estimates of the incremental cost effectiveness ratio that are consistent. The weights are functions of the estimated censoring distributions and propensity scores. Extensions are presented for quality-adjusted life years and incremental net benefit analysis. We describe the large sample properties of the estimators and present various approaches for confidence interval construction including Fieller's method and the Delta method. Empirical studies of these estimators are displayed using simulated and real data.

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