Abstract #301882

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JSM 2003 Abstract #301882
Activity Number: 448
Type: Contributed
Date/Time: Thursday, August 7, 2003 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #301882
Title: Statistical Analysis of the Effects of Trihalomethanes on Conception
Author(s): Zhigang Zhang*+ and Jianguo (Tony) Sun and Shanna H. Swan
Companies: University of Missouri, Columbia and University of Missouri and University of Missouri
Address: 2407 Whitegate Dr., Columbia, MO, 65202,
Keywords: conception ; survival analysis ; trihalomethanes ; likelihood method ; time to pregnancy
Abstract:

Trihalomethanes (THM) are common contaminants of chlorinated drinking water and their effects on premenopausal women are of considerable scientific interest to, for example, reproductive biologist and epidemiologists. Among others, one possible effect of TTHM on premenopausal women is that it may lower the probability to conception and to investigate this, some studies have been carried out. We describe two statistical methods for the analysis of the effects of TTHM on conception and other menstrual parameters. One is based on a semiparametric survival model with focus on the overall effect of TTHM on time to pregnancy and the other is based on a parametric model with focus on the effect of TTHM on day-specific probabilities of conception. We apply the methods to the Women's Reproductive Health Study, which is a prospective study of 394 premenopausal women from California.

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