Abstract #301782

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JSM 2003 Abstract #301782
Activity Number: 417
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 2:00 PM to 3:50 PM
Sponsor: Section on Teaching of Statistics in the Health Sciences
Abstract - #301782
Title: Design Issues in Ecological/Aggregate Data Studies
Author(s): Sebastien J. P. A. Haneuse*+ and Jon C. Wakefield
Companies: University of Washington and University of Washington
Address: Dept. of Biostatistics, Seattle, WA, 98195,
Keywords: ecological study ; aggregate data ; study design
Abstract:

Ecological (aggregate data) studies have a long history in the scientific literature, with focus on biases that arise from aggregation of individuals into groups. Bias may be tied down by understanding within group covariate distributions. Richardson et al. (1987) consider a parametric model, while Prentice and Sheppard (1995) introduced a semiparametric approach. Both rely on subsamples to estimate covariate distributions. Losses in precision, via the information matrix, have been considered by Sheppard and Prentice (1995) and Sheppard (2003), in the public health context of breast cancer/fat intake, as well as by Steele et a. (2003) in the social science context of age/income. We examine issues of study design, via maximizing the information, in the context of semi-ecological air pollution studies. In such studies, aggregated exposure measures are typically available, with individual level outcome/covariate data. Such associations have been found to be typically small, so that precision becomes important. Optimal choices of sub-samples (i.e., how many from each area) can lead to more accurate estimates. Such choices can depend on observed data as well as relative group sizes.


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