JSM 2003 Online Program

Abstract #301778

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Activity Number:	176
Type:	Contributed
Date/Time:	Monday, August 4, 2003 : 2:00 PM to 3:50 PM
Sponsor:	Biopharmaceutical Section
Abstract - #301778
Title:	Sample Size of Randomized Designs
Author(s):	Feifang Hu*+
Companies:	University of Virginia
Address:	Dept. of Statistics, Charlottesville, VA, 22904,
Keywords:	biased coin design ; doubly adaptive biased coin design ; power ; randomized play-the-winner rule ; sequential design ; variability
Abstract:	It is usually difficult to calculate the requisite sample size for adaptive randomized designs, because allocation probabilities keep changing during a clinical trial. For a given sample size, the number of patients in each treatment is a random variable. Therefore the power is also a random variable. For two-arm randomized designs, we derive an approximate power function for each fixed sample size. Then formulas of sample size are obtained. Some applications are discussed. Simulation results are also reported.

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