Abstract #301763

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JSM 2003 Abstract #301763
Activity Number: 298
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #301763
Title: Family-based Association Tests for Data from Different Sources
Author(s): Oksana Mokliatchouk*+
Companies: Bristol-Myers Squibb Company
Address: 305 Trinity Court, Apt. 5, Princeton, NJ, 08540,
Keywords: linkage ; quantitative traits ; family-based association tests ; pedigrees ; censored traits
Abstract:

Family-based association tests are powerful tools for locating genes on the chromosome. These tests are based on the fact that association between alleles located close to each other on the chromosome (linked alleles) dissipates more slowly than beetween unlinked alleles when chromosomes are passed from generation to generation. They are tests for association, modified in such a way that they are sensitive only to association caused by linkage, but not other factors (e.g., stratification). Modification is done, for example, by using untransmitted parental alleles as controls or conditioning on the statistic sufficient for association under the null hypothesis of no linkage. Family-based association tests for nuclear families as well as pedigrees with quantitative and censored traits, developed previously by the author, will be briefly described. Modifications of these techniques for testing for linkage in the presence of association (used for narrowing large candidate regions identified by other methods) and for traits with different censoring mechanisms will be proposed. Simulations are used to illustrate the power of these tests.

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