Abstract #301710

This is the preliminary program for the 2003 Joint Statistical Meetings in San Francisco, California. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 2-5, 2003); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2003 Program page
JSM 2003 Abstract #301710
Activity Number: 211
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #301710
Title: QoL in Oncology: A Review of Several Models in the Area Under the Curve Analysis
Author(s): Alexia Iasonos*+ and Tai-Tsang Chen and Antonella Maniero and Jan Bogaerts
Companies: Bristol-Myers Squibb Company and Bristol-Myers Squibb Company and Bristol-Myers Squibb Company and Bristol-Myers Squibb Company
Address: 5 Research Pkwy., Rm F214B, Wallingford, CT, 06492-1951,
Keywords: clinical trials ; quality of life ; area under the curve ; repeated measures
Abstract:

In oncology clinical trials, assessment of quality of life (QoL) is becoming an important endpoint. When a therapy has transient benefits or toxicity, complex patterns of QoL score changes could occur over time. For example, a toxic therapy for cancer may reduce QoL during therapy but ultimately result in a better QoL following therapy. The area under the curve (AUC) method can be used to compare overall QoL performance between two treatment arms. Multivariate models, such as repeated measures or mixed-effects models can be used to estimate the AUC. Different analytic models are examined, and an evaluation of these models is presented using an example in the phase III setting. In addition, the sensitivity of the conclusions to the model assumptions as well as other approaches will be discussed.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2003 program

JSM 2003 For information, contact meetings@amstat.org or phone (703) 684-1221. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2003