Abstract #301670

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JSM 2003 Abstract #301670
Activity Number: 402
Type: Invited
Date/Time: Wednesday, August 6, 2003 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistical Computing
Abstract - #301670
Title: Statistical Issues in Analyzing Gene Expression Data
Author(s): Yee Hwa Jean Yang*+
Companies: University of California, San Francisco
Address: 500 Parnassus Ave., MU 420 West, San Francisco, CA, 94143-0560,
Keywords: cDNA microarray ; gene expression ; experimental design ; bioinformatics
Abstract:

Microarray experiments performed in many areas of biological sciences generate large and complex multivariate data sets. This talk addresses statistical design and analysis issues, which are essential to improve the efficiency and reliability of cDNA microarray experiments. We discuss various considerations unique to the design of cDNA microarrays, and examine how different types of replication affect design decisions. We present a microarray experiment examining various mouse models that illustrate various stages involved in the design and analysis of gene expression data. A number of differentially expressed genes identified by our statistical analysis are verified by an independent biological procedure.

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Revised March 2003