Abstract #301660

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JSM 2003 Abstract #301660
Activity Number: 44
Type: Topic Contributed
Date/Time: Sunday, August 3, 2003 : 4:00 PM to 5:50 PM
Sponsor: WNAR
Abstract - #301660
Title: Pooled Sample Screening with Quality Control
Author(s): Wesley Orin Johnson*+
Companies: University of California
Address: Division of Statistics, Davis, CA, 95616,
Keywords: prevalence ; Bayesian approach ; sensitivity ; HIV testing ; diagnostic test
Abstract:

We propose a useful protocol and develop corresponding statistical methodology for the problem of screening populations for low prevalence characteristics such as HIV or drugs. For example, current screening for HIV involves testing individual blood units with an inexpensive ELISA test, followed by a more accurate Western blot test for only ELISA positive units. Our proposed strategy involves testing pooled samples both to save money and to enhance current methods by making it possible to accurately estimate the sensitivity of the initial screening test, and the prevalences of the characteristic in (i) the population at large and (ii) the population of screened units.

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