Abstract #301628

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JSM 2003 Abstract #301628
Activity Number: 378
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 12:00 PM to 1:50 PM
Sponsor: Section on Teaching of Statistics in the Health Sciences
Abstract - #301628
Title: Current Use of Statistical Techniques in AIDS Clinical Research
Author(s): Lea Li Liu*+ and Frederick Hecht and Steven Deeks and James Kahn
Companies: University of California, San Francisco and University of California and University of California and University of California
Address: 995 Potrero Ave., San Francisco, CA, 94110-2859,
Keywords: study design ; repeated measures ; AIDS ; training
Abstract:

To characterize the use of statistics in HIV clinical research, we reviewed 121 original clinical articles published in AIDS and the Journal of Infectious Disease during 2002. These articles consisted of longitudinal studies (67%), clinical trials (20%) and cross-sectional studies (13%). Power calculations were reported in 7%. Descriptive statistics only or no statistical tests were used in 3%. Basic test methods (t-test, rank sum test, χ2 or Fisher's exact test etc.) were used in 82% of the studies. Advanced techniques (correlations, linear or logistic regression and other models) were presented in 59.5%. The most frequently used methods were rank sum test (48%) and χ2 test (41%). Logistic and linear regressions were used in 21% and 16%, respectively. Survival analysis was presented in 27%, and 55% of the longitudinal studies used repeated measures. Of these, advanced repeated measure techniques were applied in 31%. There appeared to be an underutilization of statistical methodology considering the types of data generated. Intensive training in advanced statistical methodology may be needed to improve the analysts' skills and the clinicians' abilities to interpret the analyses.

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