Abstract #301320

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JSM 2003 Abstract #301320
Activity Number: 256
Type: Luncheons
Date/Time: Tuesday, August 5, 2003 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #301320
Title: Trend Test in Pharmaceuticals, How Prevalent Should It Be? - THIS LUNCHEON IS SOLD OUT
Author(s): Amit Bhattacharyya*+
Companies: GlaxoSmithKline
Address: Mail Code UW280C, King of Prussia, PA, 19406-2711,
Keywords: trend ; pair-wise comparison ; Williams test ; Cochran-Armitage test ; Mean Trend test ; Jonkheere test
Abstract:

In most clinical and nonclinical pharmaceutical safety and efficacy studies, and also in chemical studies, comparisons are made between the placebo and active doses of a treatment. If the scientific belief is that a possible dose-response relationship exists between the doses and the effects, a trend-based test should be the first choice for the experimenters or statisticians. In most cases, this is not the case. We will discuss this relevant issue with the statisticians working in the pharmaceutical and chemical industry. Discussions would reveal the prevalence of the use of trend-based tests. Should we, the practicing statisticians, promote the idea of trend-based tests more in our fields as a better alternative to the traditional pair-wise comparisons against the placebo?

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