Abstract #301311

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JSM 2003 Abstract #301311
Activity Number: 205
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Stat. Sciences
Abstract - #301311
Title: Bayesian Isotonic Regression and Trend Analysis
Author(s): Brian H. Neelon*+ and David B. Dunson
Companies: University of North Carolina and National Institute of Environmental Health Sciences
Address: 87 Granger Road, Chapel Hill, NC, 27516-4513,
Keywords: additive model ; autoregressive prior ; constrained estimation ; order restricted inference ; piecewise linear model ; trend test
Abstract:

In many applications, the mean of a response variable can be assumed to be a non-decreasing function of a continuous predictor, controlling for other covariates. In such cases, interest often focuses on estimating the response function, while also assessing evidence of an association. This article proposes a new framework for Bayesian isotonic regression and order restricted inference based on a constrained piecewise linear model with unknown knot locations. The nondecreasing constraint is incorporated through a prior distribution consisting of a product mixture of point masses (accounting for flat regions) and truncated autoregressive normal densities. This prior density is conditionally conjugate, resulting in simplified posterior computation via a Markov chain Monte Carlo algorithm. Generalizations to accommodate multiple predictors through an additive modeling structure are described, and the approach is applied to data from a study of DDE exposure and birth weight.


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