Abstract #301120

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JSM 2003 Abstract #301120
Activity Number: 402
Type: Invited
Date/Time: Wednesday, August 6, 2003 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistical Computing
Abstract - #301120
Title: Statistical Methods that Explain Biological Data by Automatically Interpreting Scientific Literature
Author(s): Soumya Raychaudhuri*+
Companies: Stanford University
Address: MSOB X-215, Stanford, CA, 94305,
Keywords: bioinformatics ; microarray ; natural language processing ; text mining ; functional genomics ; gene expression
Abstract:

High-throughput technologies permit rapid characterization of many genes simultaneously; one such method is gene expression measurements by microarray. The current challenge in bioinformatics is to devise methods to interpret the results of such large-scale experimental assays so that the properties and interactions of individual genes can be identified. To do this effectively, computational methods must integrate significant background information. Since all biological discoveries are recorded primarily in the scientific literature, the corpus of biological scientific text contains almost all of the necessary background information. I discuss our efforts at devising computational approaches that automatically access the corpus of scientific literature to analyze gene expression data. These methods draw on concepts from statistical pattern recognition and statistical text processing.


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Revised March 2003