Abstract #301104

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JSM 2003 Abstract #301104
Activity Number: 369
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #301104
Title: G-estimation of the Effect of Hormonal Contraceptives on Bacterial Cervical Infection
Author(s): Emelita M. De Leon-Wong*+
Companies: Family Health International
Address: 250 S Estes Dr., Apt. 111, Chapel Hill, NC, 27514-7000,
Keywords: g-estimation ; observational studies ; controlling bias
Abstract:

This paper will illustrate use of G-estimation in assessing the effect of hormonal contraceptives on bacterial cervical infection in a cohort of about 800 women followed every 3 months for one year. G-estimation is an analytical approach to control bias in observational study in which there exists a time-dependent risk/protective factor for the event of interest that (1) influences subsequent exposure; (2) is influenced by previous level of exposure (Robins et al. 1992). In assessing the effect of hormonal contraceptive use on acquisition of bacterial cervical infection, various behavioral factors are time-dependent that influence subsequent level of hormonal contraceptive use and may have been influenced by previous hormonal contraceptive use. For example, condom use is less likely among women who believe they are well-protected by hormonal contraceptives against pregnancy, and it is likely that women who were previously using hormonal contraceptives and condoms might have had problems with condoms. Results using time-dependent Cox regression and G-estimation will be presented.

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