Abstract #301046

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JSM 2003 Abstract #301046
Activity Number: 421
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #301046
Title: Identification of Placebo Responders Among Drug-Treated Subjects
Author(s): Thaddeus Tarpey*+ and Eva Petkova and Ying Chen and Todd Ogden
Companies: Wright State University and Columbia University and Columbia University and Columbia University
Address: Dept. of Mathematics & Statistics, Dayton, OH, 45435,
Keywords: cluster analysis ; functional data analysis ; principal points
Abstract:

Cluster analysis techniques are applied to functional data to identify placebo responders among drug-treated patients. Response profiles are estimated for each subject. Representative curves are identified using characteristics of the estimated profiles.The representative profiles identify the various types of responders including placebo responders and true drug responders. Data from a discontinuation antidepresant trial is used to estimate and test the technique.

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