Abstract #300956

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JSM 2003 Abstract #300956
Activity Number: 283
Type: Topic Contributed
Date/Time: Tuesday, August 5, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #300956
Title: Some Statistical Issues in the LC/MS Proteomics Experiments
Author(s): Li An Xu*+
Companies: Bristol-Myers Squibb Company
Address: 2735 Main St., Trenton, NJ, 08648-1014,
Keywords: proteomics ; protein expression ; LC/MS ; quality control ;
Abstract:

In the post-human genome sequence era, analysis of human proteome has no doubt become another important step to understand our biological systems. Proteomics analysis can reveal protein activities, pathway network information, and posttranscriptional information. In the past decade, instead of focusing on individual proteins, high-resolution LC/MS ion mapping technology was introduced to study the total digests of complex protein mixtures or the proteome. This shotgun approach has been successfully applied to proteome analysis, such as confirming expected masses of proteins or peptides in plasma samples. We discuss key statistical issues related to the LC/MS experiments to obtain reliable protein expression data.

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Revised March 2003