Abstract #300782

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JSM 2003 Abstract #300782
Activity Number: 298
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #300782
Title: Conditional Multipoint Linkage Analysis Using Affected Sib Pairs: An Alternative Approach
Author(s): Yen-Feng Chiu*+ and Kung-Yee Liang
Companies: National Health Research Institutes and Johns Hopkins University
Address: 128 Yen-Chiu-Yuan Rd., Sec. 2,, Taipei, Taiwan, 115, R.O.C.
Keywords: conditional ; linkage analysis ; affected sibpairs ; two-locus models ; identity by decent
Abstract:

Recently, Liang et al. (2001) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identity-by-descent) from affected sib pairs. Since markers considered are typically non-fully informative, the IBD sharing at each marker needs to be estimated (or imputed). We propose an alternative approach to deal with the IBD sharing in the reference region. This new approach makes full use of the observed data without having to categorize the imputed IBD sharing as needed in Liang et al. (2001). We compare these two approaches by simulating data from a variety of two-locus models including heterogeneity, additive and multiplicative with either fully informative markers or non-fully informative markers. The performance of both approaches is quite comparable, showing consistent estimates of the trait locus and key genetic parameters.

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