Abstract #300600

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JSM 2003 Abstract #300600
Activity Number: 112
Type: Topic Contributed
Date/Time: Monday, August 4, 2003 : 10:30 AM to 12:20 PM
Sponsor: Section on Risk Analysis
Abstract - #300600
Title: Molecular and Genetic Modeling of Disease Risk
Author(s): Edwin S. Iversen*+
Companies: Duke University
Address: ISDS, Durham, NC, 27708-0251,
Keywords: retrospective model ; gene expression data ; Bayesian analysis
Abstract:

I will describe retrospective statistical models for disease incidence, recurrence or mortality risk that incorporate detailed, i.e., high-dimensional, data on a patient's genetic profile and/or molecular phenotype. These models will be illustrated by examples drawn from ongoing projects at Duke University to characterize absolute or relative risk of particular clinical endpoints, or sets of endpoints, in context of cancer and heart disease.

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Revised March 2003