Abstract #300574

This is the preliminary program for the 2003 Joint Statistical Meetings in San Francisco, California. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 2-5, 2003); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2003 Program page
JSM 2003 Abstract #300574
Activity Number: 127
Type: Contributed
Date/Time: Monday, August 4, 2003 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #300574
Title: Penetrance Estimation of HNPCC Mutations from Family History Data
Author(s): Sining Chen*+ and Giovanni Parmigiani
Companies: Johns Hopkins University and Johns Hopkins University
Address: 550 N Broadway, Baltimore, MD, 21205,
Keywords: penetrance estimation ; HNPCC ; family aggregation ; Bayesian analysis
Abstract:

Hereditary Nonpoliposis Colorectal Cancer (HNPCC) is the most common type of familial colorectal cancer. Previous studies have shown that carriers of germline mutations on the DNA mismatch repair genes MSH2 and MLH1 have an elevated risk and earlier onset of colorectal and other cancers. With a large family-based study carried out at Creighton University with comprehensive information, we derive penetrance estimates for HNPCC mutations in a Bayesian framework. The prior comes from a meta-analysis of previously published estimates. It is then updated with a likelihood computed by MARGENE, a subroutine used by the colon cancer susceptibility model software CRCAPRO. Several statistical problems encountered in the penetrance estimation will be addressed, namely correction for ascertainment bias, adjustment for family-specific effects and extragenetic familial aggregation.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2003 program

JSM 2003 For information, contact meetings@amstat.org or phone (703) 684-1221. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2003