Abstract #300525

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JSM 2003 Abstract #300525
Activity Number: 473
Type: Contributed
Date/Time: Thursday, August 7, 2003 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #300525
Title: Exact Confidence Intervals for the Difference of Proportions
Author(s): Jimmy A. Doi*+ and Roger L. Berger
Companies: North Carolina State University and North Carolina State University & NSF
Address: 513 Tartan Circle #22, Raleigh, NC, 27606-3066,
Keywords: exact test ; two-by-two table ; unconditional distribution ; confidence interval
Abstract:

Exact confidence intervals for the difference of two independent binomial proportions are popularly used in the analysis of data stemming from clinical trials. Exact methods are best suited for studies based on small sample sizes since large sample approximation methods can perform poorly. We apply the confidence region p value method (Berger and Boos 1994) in proposing exact confidence intervals which have been found to perform better than the standard exact confidence intervals in many situations. The exact confidence intervals are based on the unconditional distribution of the binomial responses. We examine the two methods by providing coverage probability and expected length comparisons.

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