JSM 2003 Online Program

Abstract #300468

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Activity Number:	57
Type:	Contributed
Date/Time:	Sunday, August 3, 2003 : 4:00 PM to 5:50 PM
Sponsor:	Biopharmaceutical Section
Abstract - #300468
Title:	Measurement of Change
Author(s):	Timothy W. Victor*+ and Richard E. White
Companies:	AstraZeneca LP and AstraZeneca LP
Address:	732 Brooke Rd., Exton, PA, 19341,
Keywords:	change scores ; measurement ; validity
Abstract:	Measuring the magnitude of change in an attribute due to an intervention is the focus of most clinical trials. The "change from baseline" strategy is often employed, whereby scores are formed by subtracting pretest scores from posttest scores, to measure the effect of the intervention. Although the unsuitability of such scores has long been discussed, they are still commonly used, even by some otherwise sophisticated investigators. Several strategies for analyzing change will be presented and discussed. Finally, the interpretation of clinical trial data and the subsequent decisions thereof shall be explored from the perspective of measurement and statistical conclusion validity.

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