JSM 2003 Online Program

Abstract #300272

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Activity Number:	131
Type:	Contributed
Date/Time:	Monday, August 4, 2003 : 10:30 AM to 12:20 PM
Sponsor:	Biopharmaceutical Section
Abstract - #300272
Title:	Logonormal Distribution and Error Rates in Spotted Array Gene Screening
Author(s):	Borko D. Jovanovic*+ and Irene Helenowski and Marlos A. G. Viana and Raymond Bergan
Companies:	Northwestern University Feinberg and Northwestern University and University of Illinois, Chicago and Northwestern University
Address:	680 N Lake Shore Dr., Chicago, IL, 60611-4546,
Keywords:	PC3-M ; coefficient of variation ; false positives ; cell detachment ; genistein ; endoglin
Abstract:	We develop and share further insights into error rates before and after standardizing spotted microarray data (Jovanovic, et al. 2002). Logonormal distribution is used as underlying true distribution of gene expression, and ratio R=Y/X is considered the basic screening tool. We discuss parametric and nonparametric alternatives to R. We provide simulation results and examples from prostate cancer research (Liu et al. 2002).

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