Abstract #300221

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JSM 2003 Abstract #300221
Activity Number: 212
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #300221
Title: A Model for Carry-Over in Crossover Design
Author(s): Chul H. Ahn*+
Companies: Medtronic, Inc.
Address: 7000 Central Ave. NE, Minneapolis, Minnesota, 55432,
Keywords: random effect ; correlations ; heteroscedasticity ; model expansion ; score test
Abstract:

When carry-over is present in crossover design, the estimator of the treatment effect is biased. One alternative is to treat the subject effect as random and to model a combined error term with a block diagonal form for variance and covariance so that correlations between observations on the same subject are equal to r. I will consider the case where r may be different between subjects and propose the expanded model to account for different r's.

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