JSM 2003 Online Program

Abstract #300153

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Activity Number:	30
Type:	Contributed
Date/Time:	Sunday, August 3, 2003 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #300153
Title:	Testing Procedures for Group Sequential Clinical Trials with Multiple Survival Endpoints
Author(s):	Rebecca C. Scherzer*+
Companies:	Prosoft Sotware, Inc.
Address:	5930 Lovers Lane, Lower Level, Portage, MI, 49002,
Keywords:	interim analysis ; group sequential methods ; multiple comparisons ; survival analysis
Abstract:	This research gives methods for sequential monitoring of survival data in clinical trials with multiple endpoints. We propose to use weighted log rank statistics with a Lan and Demets type alpha spending function to test multiple survival endpoints at k interim analyses. To adjust for multiplicity at each interim analysis, we consider and extend methods developed by Tang and Geller (1999) and Follman, et al. (1994). These methods are motivated using survival data from a clinical study and using a simulation study.

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