Abstract #300001

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JSM 2003 Abstract #300001
Activity Number: 448
Type: Contributed
Date/Time: Thursday, August 7, 2003 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #300001
Title: Variance Estimation of Open and Fixed Cohorts on the Incidence of Cancer
Author(s): Po-Huang Chyou*+ and Hong Liang
Companies: Marshfield Medical Research Found Biostatistics and Bioinformatics Core and Marshfield Clinic Research Foundation
Address: 1000 N Oak Ave., Marshfield, WI, 54449-5703,
Keywords: Variance ; Open ; Fixed ; Cohort ; Incidence ; Permutation
Abstract:

In epidemiological research, two prospective cohort study designs, open and fixed cohorts, can be used to assess the incidence of cancer or other chronic diseases. After a long period of follow-up, attrition rate and increased variance of incidence rate estimation due to a small number of cases in the fixed cohort may induce serious concerns. To improve the precision of incidence rate, we propose permutation approach and direct mathematical derivation to evaluate the probability that the variance of incidence rate among the open cohort is no more than that of the fixed cohort. Results are compared between the two groups based on simulation analyses and a real dataset. The findings are discussed in this paper.

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