Abstract #301985

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JSM 2002 Abstract #301985
Activity Number: 81
Type: Contributed
Date/Time: Monday, August 12, 2002 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section*
Abstract - #301985
Title: Critical Assessment of Error Models in the Analysis of Microarray Experiments
Author(s): Georgiy Bobashev*+
Affiliation(s): RTI International
Address: 3040 Cornwallis Road, RTP, NC, 27709, USA
Keywords: microarray ; variance components ; error models ; ANOVA ; gene specific variation
Abstract:

Microarray technology allows for simultaneously measuring expression of a large number of genes. Currently, the most widely used techniques for the analysis of differential gene expression are ANOVA-type models. At present, researchers are using a number of different assumptions about the structure of gene variance in these models. These variance assumptions are not always in agreement with each other. We present a study in which we address the issues of gene-specific variance, assumptions of normality, and prior information about the variance from a collection of experimental microarray data.

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Revised March 2002