Abstract #301865

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JSM 2002 Abstract #301865
Activity Number: 110
Type: Contributed
Date/Time: Monday, August 12, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section*
Abstract - #301865
Title: An Aid to Monitoring Phase II Studies in Cancer
Author(s): Gary Rosner*+ and Hyung-Woo Kim
Affiliation(s): U. T. M. D. Anderson Cancer Center and U. T. M. D. Anderson Cancer Center
Address: 1515 Holcombe Blvd., 447, Houston, Texas, 77030, USA
Keywords: Bayesian methods ; Clinical trials ; Data monitoring
Abstract:

In medical oncology, phase II studies evaluate activity of anticancer drugs by evaluating the proportion of patients who respond to therapy. Response is usually measured as tumor shrinkage beyond some criterion. Not all patients' tumors respond within the same amount of time, however, and the time factor is generally not considered when monitoring phase II studies. We describe a method for incorporating time until response to add information to monitoring phase II clinical studies. We illustrate the method and make comparisons to designs in common use.

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