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Activity Number:
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81
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Type:
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Contributed
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Date/Time:
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Monday, August 12, 2002 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section*
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| Abstract - #301723 |
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Title:
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Change-Point Analysis of Array-based Comparative Genomic Hybridization Data
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Author(s):
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Adam Olshen*+ and E. Venkatraman
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Affiliation(s):
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Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center
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Address:
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1275 York Avenue, New York, New York, 10021, USA
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Keywords:
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change-point ; CGH
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Abstract:
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Cancer progression often involves alterations in DNA sequence copy number. Conventional comparative genomic hybridization (CGH) is a technology for assessing copy number losses or gains across entire genomes. Recently, an array-based version of CGH (aCGH) was introduced to overcome the resolution limits of the conventional method. As is the case with cDNA microarray experiments of gene expression, the copy number for a mapped sequence on a genome is related to a test over reference fluorescent intensity ratio. Our goal is to make accurate genome-wide maps of copy number of subjects undergoing aCGH studies from the noisy intensity ratios. These maps would be beneficial for associating aberrations with clinical or other response variables and for identification of potentially useful genes. We have developed novel modifications of both binary and sequential change-point methods for this purpose. The methods are compared on both simulated and real aCGH data.
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