Abstract #301660

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JSM 2002 Abstract #301660
Activity Number: 318
Type: Contributed
Date/Time: Wednesday, August 14, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section*
Abstract - #301660
Title: MAXIMA: Exact Tests for Linkage Analysis
Author(s): Chih-Chieh Wu*+
Affiliation(s): U. T. M. D. Anderson Cancer Center
Address: Box189, 1515 Holcombe Blvd, Houston, Texas, 77030, USA
Keywords: identity by descent ; linkage test ; maxima ; power
Abstract:

A new exact test statistic, Max, for sharing two alleles identity by descent (IBD) by affected sib pairs is presented. The test statistic, Max, is the maximum occupancy number based on the equiprobable multinomial distributions with four cells. The reverse-cumulative distribution function, which is used for P-values computation and moments of Max, are exact and derived by combinatorial mathematics. The test, Max, is also extended to multilocus models. Problems concerning comparisons of power between new methods based on Max and the existing tests, including the maximum lod score test by Risch (1990), the mean test, the two-allele test, and the Pearson chi-squared goodness-of-fit test, are considered.

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Revised March 2002