Abstract #301653

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JSM 2002 Abstract #301653
Activity Number: 189
Type: Invited
Date/Time: Tuesday, August 13, 2002 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology*
Abstract - #301653
Title: Mapping Complex Disease Genes Using Many Tightly Linked Genetic Markers
Author(s): Hongyu Zhao*+
Affiliation(s): Yale University
Address: 60 College Street, New Haven, Connecticut, 06520, USA
Keywords: statistical genetics ; haplotypes ; complex traits ; genotyping error ; association
Abstract:

With the availability of hundreds of thousands of genetic markers in the human genome, it is becoming feasible in genetic association studies of complex traits to genotype thousands to thousands of markers, and to saturate candidate regions with many tightly linked genetic markers. The analysis of such data poses many statistical challenges, including the control of population stratification, the analysis of haplotypes, the relative merit of various genotyping strategies, and multiple comparisons. In this presentation, we will discuss statistical issues in the collection and analysis of haplotypes from population-based samples with an emphasis on marker selections and genotyping errors.

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Revised March 2002