Abstract #301625

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JSM 2002 Abstract #301625
Activity Number: 185
Type: Contributed
Date/Time: Tuesday, August 13, 2002 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistical Computing*
Abstract - #301625
Title: Population PK/PD Models Using SAS Macro NLINMIX
Author(s): Andrzej Galecki*+ and Russ Wolfinger
Affiliation(s): University of Michigan and SAS Institute Inc.
Address: 300 NIB Rm. 923, Ann Arbor, Michigan, 48109-2007, USA
Keywords: Mixed effects models ; Nonlinear models ; Population PK/PD models ; Linearization method ; SAS macro ; IML interface
Abstract:

Population pharmacokinetics and pharmacodynamics (PK/PD) data consist of repeated measurements taken on each of a number of individuals. In PK studies, blood samples are drawn several times from each subject to investigate levels of a test agent in the blood and/or in the body over time. In PD studies, we measure a physiological effect of a drug administered using different doses. Both population PK and PD data can be analyzed in the framework of nonlinear mixed effects models. In this presentation, we discuss some recent changes in the NLINMIX, including a SAS/IML interface to specify population PK/PD models as the solution of a system of ordinary differential equations (ODE). An example using indomethacine data provides illustration.

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