Abstract #301598

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JSM 2002 Abstract #301598
Activity Number: 212
Type: Contributed
Date/Time: Tuesday, August 13, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section*
Abstract - #301598
Title: Limitations in Instrumental Variables Estimation of Dose-response
Author(s): Marshall Joffe*+
Affiliation(s): University of Pennsylvania
Address: 602 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania, 19004-6021, USA
Keywords: causal inference ; instrumental variables ; randomized trials
Abstract:

Instrumental variables methods have been proposed for use in estimating treatment effects in randomized trials with noncompliance, using the randomization indicator as the instrument. Unfortunately, the coefficients in structural models fit using instrumental variables or G-estimation methods do not necessarily represent the correct population dose-response curve, i.e., the dose-response curve were it possible to make subjects take the stated dose. This may be seen by elaborating the models fit. These points are illustrated with data from the Lipid Research Clinics-Coronary Primary Prevention Trial, a randomized trial of a cholesterol-lowering drug.

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Revised March 2002