Abstract #301272

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JSM 2002 Abstract #301272
Activity Number: 387
Type: Contributed
Date/Time: Thursday, August 15, 2002 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section*
Abstract - #301272
Title: Multiplicity Adjustment in Pearson's Correlation between Molecular Activity and the Target Protein Structure
Author(s): Lei Zhu*+ and Keefer Chris
Affiliation(s): GlaxoSmithKline, Inc. and Cheminformatics
Address: RTP, Raleigh, North Carolina, 27709-3398, USA
Keywords: Resampling ; Pearson's Correlation ; Drug Discovery ; Multiplicity Adjustment
Abstract:

There is a desire to correlate small molecule activity with biological target structure. One approach is to calculate Pearson's correlations between molecular activity profiles and protein sequence descriptors. The difficulty in this approach is to identify significant correlation among the large number of correlation coefficients. Simple Bonferroni adjustment is too conservative, due to the large number of correlated tests. Multiple testing using the resampling approach is applied. Results from the raw p-values and different multiplicity adjustment approaches are demonstrated. With multiplicity adjustment, we can identify real correlations between drug target and molecular activity.

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Revised March 2002