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Activity Number:
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182
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Type:
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Contributed
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Date/Time:
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Tuesday, August 13, 2002 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section*
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| Abstract - #301215 |
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Title:
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Comparing Immunohistochemical Data Using Kendall's Tau
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Author(s):
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David Verbel*+ and Jaya Satagopan and Carlos Cordon-Cardo
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Affiliation(s):
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Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center
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Address:
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1275 York Ave., New York, New York, 10021, USA
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Keywords:
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Abstract:
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IHC is a technique used in pathology laboratories to assess the presence of specific antigens in tissues through the use of either fluorescent dyes or enzymes. Tumor tissues are stained for markers of interest, and the percentage of cells staining positive for that marker are reported as IHC expression data. As a result of increased use of tissue microarrays, IHC data are rapidly being collected and analyzed with little review of the statistical methods used. Interactions between tumor markers are evaluated by testing for associations between their expression levels using Kendall's tau or tau-b. These measures differ in how they handle tied observations and could therefore produce conflicting results and conclusions. Different commercially available software packages often report only one or the other of these measures of association, but not both. Thus, it is necessary to understand how these measures differ and which measure the investigator is reporting. We describe the underlying differences between the two measures and show that consistent results can be obtained using permutation-based methods. This is illustrated using a bladder cancer example from MSKCC.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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