Abstract #301149

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JSM 2002 Abstract #301149
Activity Number: 92
Type: Topic Contributed
Date/Time: Monday, August 12, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section*
Abstract - #301149
Title: A Nonparametric Procedure for the Analysis of Balanced Crossover Designs
Author(s): Francois Bellavance*+ and Serge Tardif and Constance van Eeden
Affiliation(s): HEC Montreal and Université de Montréal and University of British Columbia
Address: 3000 chemin de la Cote-Sainte-Catherine, Montreal, Quebec, H3T 2A7, Canada
Keywords: Permutation tests ; crossover designs ; balanced designs
Abstract:

Nonparametric tests will be presented for the hypotheses of no-direct treatment and carryover effects for balanced M-period M-treatment crossover designs. The design consists of n replicates of balanced crossover designs. The tests are permutation tests based on the n vectors of least squares estimators of the parameter of interest obtained from the n replications of the experiment. The exact, as well as the asymptotic, distribution of the test statistics are obtained, and it is shown that the tests have, asymptotically, the same power as the F-ratio test.

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