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Activity Number:
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21
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Type:
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Contributed
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Date/Time:
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Sunday, August 11, 2002 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section*
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| Abstract - #301141 |
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Title:
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Characterizing Profiles of Repeated Cognitive Measures in Alzheimer's Disease Patients
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Author(s):
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Hyonggin An*+ and Roderick Little+ and Andrea Bozoki
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Affiliation(s):
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University of Michigan and University of Michigan and Michigan State University
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Address:
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1420 Washington Heights, SPH II, M4048E, Ann Arbor, Michigan, 48109, U.S.A. 1420 Washington Heights, Ann Arbor, Michigan, 48109-2029, USA
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Keywords:
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Alzheimer's disease ; Repeated measurements ; Plateau
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Abstract:
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Repeated neuropsychological measurements are frequently used in Alzheimer's disease (AD) research in order to study change in cognitive function of AD patients. A question of interest among dementia researchers is whether some AD patients exhibit transitory "plateaus" of cognitive function in the course of the disease. We consider a statistical approach to this question, based on unbalanced and irregularly-spaced repeated neuropsychological measurements. Main statistical tasks are used to define an algorithm for the measurement of a cognitive plateau and to test the existence of plateaus in AD using results from this algorithm. In this talk, an algorithm is proposed and a randomization test based on simulating data sets from a linear mixed model will be described. The proposed method is applied to a longitudinal data set from the Michigan Alzheimer's Disease Research Center.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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