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Activity Number:
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69
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Type:
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Contributed
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Date/Time:
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Monday, August 12, 2002 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology*
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| Abstract - #301086 |
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Title:
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A New Method of Fine Mapping of Genes of Diseases with Multiple Ancestral Haplotypes and Allelic Heterogeneity
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Author(s):
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Renfang Jiang*+ and Jianping Dong+
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Affiliation(s):
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Michigan Technological University and Michigan Technological University
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Address:
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1400 Townsend Dr., Houghton, Michigan, 49931, USA 1400 Townsend Dr., Houghton, Michigan, 49931, USA
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Keywords:
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fine mapping ; complex diseases ; allelic heterogeneity ; linkage disequilibrium ; multiple ancestral haplotype ; association analysis
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Abstract:
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The current emphasis of association study has shifted toward locating genes for common complex diseases. The hope is that association analysis can identify genes responsible for complex diseases, which will lead to early diagnosis and treatment of chronic common diseases. The aim of this paper is to introduce a new fine-mapping method, using haplotype data from cases and controls for diseases with allelic heterogeneity (multiple disease alleles with multiple ancestral haplotypes). Terwilliger and Weiss (1998) point out that the allelic heterogeneity disease model fits many diseases, such as the macroscopic level for BRCA1, retinitis pigmentosa, cystic fibrosis, and many others . The existing association measures do not work well because of multiple ancestral haplotypes and multiple disease alleles. Simulations show that our new method will work well even for diseases with allelic heterogeneity and multiple ancestral haplotypes. We also give a theoretical proof of why it works. The new measures will be consistent, and we find their asymptotic bias and variance. If the haplotype data are nor available, we will estimate them from the genotype data.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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