Abstract #301080


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JSM 2002 Abstract #301080
Activity Number: 92
Type: Topic Contributed
Date/Time: Monday, August 12, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section*
Abstract - #301080
Title: A Note on ANOVA Assumptions and Robust Analysis for a Crossover Study
Author(s): Xun Chen*+
Affiliation(s): Merck Research Laboratories
Address: RY34-A304, Rahway, New Jersey, 07065, usa
Keywords: Crossover ; Robust
Abstract:

Analysis of variance (ANOVA) methods are usually applied to analyze continuous data from crossover studies. The analysis, however, may not have appropriate type I error when certain assumptions are violated. In this paper, we first clarify a conventionally minimum set of assumptions that validate the F-tests of ANOVA models for crossover studies. We then provide a practical verification/remedy procedure based upon the theoretical developments. By applying the verification/remedy procedure, more robust analysis results can be expected from the ANOVA models.


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