Abstract #301062

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JSM 2002 Abstract #301062
Activity Number: 364
Type: Contributed
Date/Time: Wednesday, August 14, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section*
Abstract - #301062
Title: A Mixture-of-Genotypes Model for the Distribution of Thermostable Phenol Sulfotransferase Activities
Author(s): Jungnam Joo*+ and Hongshik Ahn+ and Robert Delongchamp
Affiliation(s): State University of New York, Stony Brook and State University of New York, Stony Brook and National Center for Toxicologicial Research
Address: State University of New York at Stony Brook, Stony Brook , New York, 11794-3600, USA , Stony Brook, New York, 11794-3600, U.S.A
Keywords: Density estimation ; EM algorithm ; Genotype ; Phenotype
Abstract:

A statistical method for parametric density estimation based upon a mixture-of-genotypes model is developed for the thermostable phenol sulfotransferase (SULT1A1) activity, which has a putative role in modifying risk for colon cancer or colon polyps. In this study, an EM algorithm for the general mixture model is modified to accommodate the constraints on the mixing proportions and is used to estimate allele and genotype frequencies from the distribution of the SULT1A1 phenotype. The relative risk associated with genotypes defined by this model is also investigated through the generalized linear model.

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