Abstract #301031

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JSM 2002 Abstract #301031
Activity Number: 81
Type: Contributed
Date/Time: Monday, August 12, 2002 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section*
Abstract - #301031
Title: A Statistical Model for Investigating Binding Probabilities of DNA Nucleotide Sequences Using Microarrays
Author(s): Mei-Ling Lee*+ and George Whitmore
Affiliation(s): Harvard University and McGill University
Address: 181 Longwood Ave, Boston, Massachusetts, 02115, USA
Keywords: gene expression ; microarrays ; log-linear probabilities
Abstract:

There is considerable scientific interest in knowing the probability that a given site-specific transcription factor will bind to a given DNA sequence. Microarray methods provide an effective means for assessing the binding affinities of a large number of DNA sequences, as demonstrated by Bulyk et al (2001a) in their study of the DNA-binding specificities of Zif268 zinc fingers using microarray technology.

We present a general statistical methodology for analyzing microarray intensity measurements reflecting DNA-protein interactions.

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