Abstract #301000

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JSM 2002 Abstract #301000
Activity Number: 214
Type: Contributed
Date/Time: Tuesday, August 13, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section*
Abstract - #301000
Title: Use of Hazard Ratio in Comparing Survival Distributions
Author(s): Mani Lakshminarayanan*+
Affiliation(s): Centocor, Inc
Address: 200 Great Valley Parkway, Malvern, Pennsylvania, 19355-1307, USA
Keywords: Time to event ; Survivor function ; Cumulative hazard ; Sample size ; Exponential survivals
Abstract:

In cardiovascular and oncology clinical trials, time to a specific event (e.g., death) is typically considered as a primary endpoint. Suppose, the primary objective of an oncology clinical trial is to compare the efficacy of a new cancer treatment with that of a standard treatment. For this trial, the sample size calculations may be done based on mean failure times--viz, hazard rates are expressed in terms of mean failure times. In this paper, we will show how the different metrics in comparing survival curves can be expressed in terms of hazard ratio, thus making it easier to interpret the hazard ratio, and to do sample size calculations. Examples will be described in terms of standard survival distributions.

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Revised March 2002