Abstract #300985

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JSM 2002 Abstract #300985
Activity Number: 155
Type: Contributed
Date/Time: Monday, August 12, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section*
Abstract - #300985
Title: Effective Dose Estimation with Multi-Factor Models
Author(s): Bill Pikounis*+
Affiliation(s): Merck & Company, Inc.
Address: PO Box 2000, Bldg RY70-38, Rahway, New Jersey, 07065-0900, USA
Keywords: Antifungal ; LD50 ; EC50
Abstract:

Consider a designed study where antibiotics are evaluated for their dose-response behavior against different fungal or bacterial strains. The desired endpoint might be survival, or it might be the reduction of disease prevalence in a target organ. An approach of fitting a single model to the pooled study data is taken, with dose, compounds, and strains specified as predictors. Then the estimated parameters are used from this single model to construct functions to estimate effective dose quantiles. With goals of maximizing accuracy, precision, and interpretation of such estimates, some interesting issues come about for model specification, practical calculation, and reporting of results.

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Revised March 2002