Abstract #300946

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JSM 2002 Abstract #300946
Activity Number: 191
Type: Invited
Date/Time: Tuesday, August 13, 2002 : 10:30 AM to 12:20 PM
Sponsor: Section on Physical & Engineering Sciences*
Abstract - #300946
Title: Empirical Validation of Design Principles for cDNA Microarrays: A "Proof of Principle" Experiment
Author(s): Kathleen Kerr*+ and Gary Churchill and Hao Wu and John Quackenbush and Shuibang Wang
Affiliation(s): University of Washington and The Jackson Laboratory and The Jackson Laboratory and The Institute for Genomic Research and The Institute for Genomic Research
Address: Box 357232,, Seattle, Washington, 98133, USA
Keywords: gene expression ; cDNA microarray ; ANOVA ; experimental design
Abstract:

Microarray experiments represent a substantial investment of time and resources. The power of a microarray study is greatly affected by the experimental design employed. We will review the principles of experimental design as they pertain to microarray studies, and then discuss results from an experiment where the same RNA samples were studied using two different experimental plans. The theoretical relative efficiency of the two designs will be compared with the actual results. In addition, we introduce refinements of ANOVA modeling of microarray data and inferential tools for gene expression data.

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Revised March 2002