Abstract #300942

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JSM 2002 Abstract #300942
Activity Number: 290
Type: Contributed
Date/Time: Wednesday, August 14, 2002 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section*
Abstract - #300942
Title: Dose Response Modelling with Side Effects and Covariates
Author(s): Manel Wijesinha*+
Affiliation(s): Pennsylvania State University, York
Address: 1031 Edgecomb Ave, York, Pennsylvania, 17403, USA
Keywords: dose response ; side effects ; covariates
Abstract:

The main objective of this work is to introduce a new way of defining dose response models. The "success" event in this new approach is defined to be a positive response with no side effects. In this setting , the functional form of p, probability of success, vs. dose level can be modeled to be in parabolic form. Furthermore, the effect of covariates will be incorporated into the model so that the dose response curve will be variable for different covariate levels. As a result of this new development, optimal doses which are more patient-specific can be obtained.

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Revised March 2002