Abstract #300486

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JSM 2002 Abstract #300486
Activity Number: 155
Type: Contributed
Date/Time: Monday, August 12, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section*
Abstract - #300486
Title: Q-TWiST Analysis for Neoadjuvant Cancer Trials
Author(s): Kao-Tai Tsai*+
Affiliation(s): Aventis Pharmaceuticals
Address: 300 Somerset Corporate Centers, Bridgewater, New Jersey, 08807, USA
Keywords: Clinical trials ; Oncology ; Q-TWiST
Abstract:

Analysis of Quality-adjusted Time Without Symptoms and Toxicities (Q-TWiST) has been gaining more attention in adjuvant cancer trials that assume four progression steps, namely, toxicity, time without symptoms and toxicities, relapse, and death. However, this four-step progression setting is not applicable in the neoadjuvant cancer trials. In this paper, we address the analytical issues of Q-TWiST as an endpoint for the neoadjuvant studies. Examples from the recent oncology trials will be used to demonstrate the applications of this procedure.

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Revised March 2002