Abstract #300464

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JSM 2002 Abstract #300464
Activity Number: 111
Type: Contributed
Date/Time: Monday, August 12, 2002 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section*
Abstract - #300464
Title: Ratios, Standardization and Error Rates in cDNA Microarray Gene Screening
Author(s): Borko Jovanovic*+ and Raymond Bergan and Marlos Viana
Affiliation(s): Northwestern University Medical School and Northwestern University Medical School and University of Illinois
Address: 680 N Lake Shore Drive, Suite 1102, Chicago, Illinois, 60611, usa
Keywords: ratio ; gamma distribution ; monte-carlo ; gene screening ; housekeeping genes ; landing lights
Abstract:

We use numerical simulation to examine error rates in cDNA microarray gene screening, with particular emphasis on methods of standardization (or normalization) of observed intensity values. It is assummed that underlying intensities of radioactive dye measuring presence of cDNA and, therefore, expression of particular genes, follows a Gamma (a,b) distribution and that two underlying parameters--a, b--each have a Gamma distribution as well. We utilize prior information from an earlier study of 3,582 genes (Jovanovic et al., AJPhGen 1(2);145-152).

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Revised March 2002