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Activity Number:
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234
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Type:
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Invited
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Date/Time:
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Tuesday, August 13, 2002 : 2:00 PM to 3:50 PM
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Sponsor:
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IMS
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| Abstract - #300420 |
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Title:
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Family Based Association Tests with Haplotypes
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Author(s):
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Nan Laird*+
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Affiliation(s):
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Harvard School of Public Health
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Address:
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677 Huntington Ave, Boston, Massachusetts, 02115, USA
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Keywords:
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Abstract:
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Family-based tests of association are widely used in searching for the genetic basis of disorders. Much of the literature deals with the construction of unbiased tests when dealing with a single marker; the marker values of parents may be missing, but that of the offspring is assumed to be fully observed. It is increasingly common to use haplotypes composed of multiple markers in tests of association. With haplotypes, missing information can arise in both parents and offspring. One approach relies on using estimated probabilities for parental and offspring haplotypes to construct weighted tests (Clayton, AJHG,1999). We describe a conditioning approach that can accommodate both lack of phase and incomplete genotyping in parents and/or offspring. The conditioning approach yields unbiased tests, but may discard considerable information if phase cannot be resolved. We will provide comparisons of these two basic approaches and discuss tradeoffs.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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