Abstract #300193


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JSM 2002 Abstract #300193
Activity Number: 164
Type: Invited
Date/Time: Tuesday, August 13, 2002 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistical Computing*
Abstract - #300193
Title: Modeling Molecular Substitution
Author(s): Von Yap*+
Affiliation(s): University of California, Berkeley
Address: , , , ,
Keywords: DNA substitution ; Markov chain ; alignment ; molecular evolution ; maximum likelihood
Abstract:

Molecular evolution refers to the gradual changes in DNA composition as it is passed down through generations of organisms. While this process is usually too slow to be observed directly, alignment of related DNA sequences across species provides indirect evidence of its operation. Substitution is the replacement of a DNA base by another base. A reversible time-continuous Markov chain is normally used to model this process. We will discuss maximum likelihood estimation of the model parameters based on aligned sequence data and how this procedure may help devise better sequence alignment methods.


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