Abstract #300090

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JSM 2002 Abstract #300090
Activity Number: 161
Type: Invited
Date/Time: Tuesday, August 13, 2002 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Stat. Sciences*
Abstract - #300090
Title: Hierarchial Modeling of Clinical Safety Data
Author(s): Donald Berry*+
Affiliation(s): U. T. M. D. Anderson Cancer Center
Address: 1515 Holcombe Blvd, Houston, Texas, 77030, USA
Keywords:
Abstract:

A standard and important part of the drug development process is assessing rates of hundreds of adverse effects. Traditional frequentist adjustments for multiple comparisons are much too conservative for this purpose. I propose a Bayesian hierarchical modeling approach in which adverse effects are nested within body systems and there is borrowing of strength within and across systems. I compare this approach with traditional frequentist approaches.

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