Abstract #300039

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JSM 2002 Abstract #300039
Activity Number: 340
Type: Invited
Date/Time: Wednesday, August 14, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section*
Abstract - #300039
Title: Measuring Sensitivity to Nonignorable Dropout in the Analysis of Quality-of-Life Data
Author(s): Andrea Troxel*+ and Guoguang (Julie) Ma and Daniel Heitjan
Affiliation(s): Columbia University and Merck & Company, Inc. and Columbia University
Address: 622 W. 168th St., New York, New York, 10032, USA
Keywords: ignorability ; missing at random ; prostate cancer ; sensitivity analysis
Abstract:

Standard methods of analysis can give misleading results when some observations are nonignorably missing. Assessment of nonignorability by estimating a nonignorable model is problematic, however, because the numerical work can be difficult, and estimates can be sensitive to untestable assumptions. Recently, Troxel, Ma and Heijtan (2002) proposed an index of sensitivity to nonignorability for a normal linear model; Ma and Heitjan (2002a, 2002b) extended this work to the generalized linear model and to longitudinal data. We present a detailed example demonstrating the use of this index in an analysis of longitudinal quality-of-life data from a prostate cancer clinical trial.

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